COVID-19 Outbreak Information Updates (Reboot) [over 150.000,000 US cases (est.), 6,422,520 US hospitilizations, 1,148,691 US deaths.] (9 Viewers)

Next up..... Astra Zeneca and Oxford University vaccine. This one could prove to be a MAJOR game changer because of the possible level of overall production of this vaccine. This vaccine is being produced in multiple countries and multiple facilities. It is hard to get a handle on how many doses may be produced before the end of 2020, but the worldwide total could be in the hundreds of millions of doses. The USA is in line for maybe 1/3 of that total.

I suspect that the Astra Zeneca and Oxford University vaccine will have Phase 3 results in about 4-5 weeks and seek Emergency Use Authorization before the end of 2020 and will likely get approval. (I also think that it is possible that they file for approval in the UK or The EU at the same time or even sooner than the USA.)

This vaccine, IF safe and effective, is a massive game changer because of the scale of production. My best read on this one is that a few hundred million doses will be produced before the end of 2020, on multiple continents. (A major facility in India has been producing this vaccine "at risk" since the Summer, they may have over 100 million doses from that one company produced already.)

"Researchers say the Lancet phase two findings, based on 560 healthy adult volunteers, are "encouraging".
They are also testing whether the vaccine stops people developing Covid-19 in larger, phase three trials."
" The Oxford data is from an earlier stage, which tests the safety of the vaccine and the body's response to it, but in the long run it's likely this vaccine could be easier to roll out because it doesn't need to be stored at very cold temperatures. "
"Prof Andrew Pollard, study lead from the University of Oxford, told the BBC he was "absolutely delighted with the results" showing a strong immune response "even in those over 70 years of age".
On whether the vaccine protects people against Covid-19, he said they were "not there yet" but the data would probably be released "before Christmas".
" Two weeks after the second dose, more than 99% of participants had neutralising antibody responses. These included people of all ages. "


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FYI, the US Government signed a contract for 300 million doses in May.

 
Just found out my son’s school in St Tammany will close 14 days until December because of COVID outbreak. St. Tammany cases and positive numbers have increased the past week.
 
Let's talk vaccines:

1. The Pfizer and Moderna vaccines are based on mRNA tech, right? I know there are some basic (but significant for a few) side effects similar to flu vaccinations, but what possible long-term issues may be present with this? Is it a case of "we don't know what we don't know" at this point? I know the issues with the first polio vaccine back in the day came about pretty quickly and vaccine tech was new at that time, so are we really worried about safety of the vaccine in this day and age?

2. I keep seeing all of these companies have been producing vaccine ahead of time in the hopes they work. Great. I also see that the vaccines have to be stored properly. That would lead me to believe they have an "expiration date" of sorts. How can they produce large quantities that far ahead of time and keep them stable? Very cold storage, I guess?

3. I asked this several pages ago, but it got no reply, so tossing it in again here. Once we get the vaccine and get the second shot and build immunity, the vaccinated individual is protected. At that point, can the person still be a carrier who could spread it to those who are not vaccinated? (I know people will say, "Then they should get the vaccine." Let's ignore that a moment.)
 
3. I asked this several pages ago, but it got no reply, so tossing it in again here. Once we get the vaccine and get the second shot and build immunity, the vaccinated individual is protected. At that point, can the person still be a carrier who could spread it to those who are not vaccinated? (I know people will say, "Then they should get the vaccine." Let's ignore that a moment.)

From what I understand of how vaccines work, you either have the virus, or you don't. I don't think it could be lurking in your respiratory system in a non-virulent way. Based on immunity from the vaccine, if the body detects the virus, it attacks and kills it. I could be wrong, and maybe it lies in a dormant state. But god I hope not.
 
From what I understand of how vaccines work, you either have the virus, or you don't. I don't think it could be lurking in your respiratory system in a non-virulent way. Based on immunity from the vaccine, if the body detects the virus, it attacks and kills it. I could be wrong, and maybe it lies in a dormant state. But god I hope not.
Based on history of vaccines, my answer would be no. Getting vaccinated against the flu doesn't make you a carrier.
 
From what I understand of how vaccines work, you either have the virus, or you don't. I don't think it could be lurking in your respiratory system in a non-virulent way. Based on immunity from the vaccine, if the body detects the virus, it attacks and kills it. I could be wrong, and maybe it lies in a dormant state. But god I hope not.

I have heard otherwise, but I don't remember where from or whether it was credible. I think it was an in-person conversation from someone that should know, but I also wasn't paying that much attention.
 
1. The Pfizer and Moderna vaccines are based on mRNA tech, right? I know there are some basic (but significant for a few) side effects similar to flu vaccinations, but what possible long-term issues may be present with this? Is it a case of "we don't know what we don't know" at this point? I know the issues with the first polio vaccine back in the day came about pretty quickly and vaccine tech was new at that time, so are we really worried about safety of the vaccine in this day and age?

I have concerns because the mRNA is new technology. The concern I have seen longterm is that it could change your immune system in a way that it could malfunction somehow significantly down the road (antibodies attacking healthy cells and such). I haven't seen that it will happen, just speculation that if something were to go wrong, that could be the thing.

It's probably not going to keep me from getting the vaccine (and I only say probably because if there is a different type of vaccine available, I might opt for that), but that's the concern I've read about.
 
Let's talk vaccines:

1. The Pfizer and Moderna vaccines are based on mRNA tech, right? I know there are some basic (but significant for a few) side effects similar to flu vaccinations, but what possible long-term issues may be present with this? Is it a case of "we don't know what we don't know" at this point? I know the issues with the first polio vaccine back in the day came about pretty quickly and vaccine tech was new at that time, so are we really worried about safety of the vaccine in this day and age?

2. I keep seeing all of these companies have been producing vaccine ahead of time in the hopes they work. Great. I also see that the vaccines have to be stored properly. That would lead me to believe they have an "expiration date" of sorts. How can they produce large quantities that far ahead of time and keep them stable? Very cold storage, I guess?

3. I asked this several pages ago, but it got no reply, so tossing it in again here. Once we get the vaccine and get the second shot and build immunity, the vaccinated individual is protected. At that point, can the person still be a carrier who could spread it to those who are not vaccinated? (I know people will say, "Then they should get the vaccine." Let's ignore that a moment.)

1. Long term, we don't know for sure. From what I know and people I have spoken with who have a pretty good understanding of this, the mRNA vaccines should have no long term negative side effects. (They may even help against the cold?) Technology is WAY more advanced than it was even just five years ago. The last 20 years has seen advances in Science on a par with cell phones. It is crazy how much they know now.

2. They can be kept in very cold storage (mRNA vaccines) or they only require refrigeration to be kept stable for months. The major ramp up in production started in the last 2-3 months and these pretty much will all have a shelf (cold) life of several months. Some of the next ones should be even more stable for longer periods. Astra, JNJ Sanofi, etc, all look to have longer shelf lives or less storage/cooling requirements.

3. Vaccine should make you good to go, but still with understanding that the first two look to be 95% effective. Need MANY people to get the shots to really tamp this thing down for good. (Might not ever go "away" but could be decreased significantly so that it is less of a worry than the seasonal flu.) Effective vaccine should mean that a person cannot spread disease.

Given all of that, I would be willing to get shot up in both arms with the Pfizer or Moderna vaccines today. Assuming, Astra comes back good, they can have a leg. (You will only get one vaccine, this is a joke.)
 
1. Long term, we don't know for sure. From what I know and people I have spoken with who have a pretty good understanding of this, the mRNA vaccines should have no long term negative side effects. (They may even help against the cold?) Technology is WAY more advanced than it was even just five years ago. The last 20 years has seen advances in Science on a par with cell phones. It is crazy how much they know now.

2. They can be kept in very cold storage (mRNA vaccines) or they only require refrigeration to be kept stable for months. The major ramp up in production started in the last 2-3 months and these pretty much will all have a shelf (cold) life of several months. Some of the next ones should be even more stable for longer periods. Astra, JNJ Sanofi, etc, all look to have longer shelf lives or less storage/cooling requirements.

3. Vaccine should make you good to go, but still with understanding that the first two look to be 95% effective. Need MANY people to get the shots to really tamp this thing down for good. (Might not ever go "away" but could be decreased significantly so that it is less of a worry than the seasonal flu.) Effective vaccine should mean that a person cannot spread disease.

Given all of that, I would be willing to get shot up in both arms with the Pfizer or Moderna vaccines today. Assuming, Astra comes back good, they can have a leg. (You will only get one vaccine, this is a joke.)

My question is will it be a one time shot,or require yearly vaccinations like the flu.
 

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