COVID-19 Outbreak Information Updates (Reboot) [over 150.000,000 US cases (est.), 6,422,520 US hospitilizations, 1,148,691 US deaths.] (5 Viewers)



Vaccines made from mRNA can be made much faster than older vaccines could, explains Margaret Liu, a vaccine researcher who chairs the board of the International Society for Vaccines and specializes in genetic vaccines. The problem, says Liu, is that mRNA is "really easily destroyed, and that's because there are many, many enzymes that will just break it apart."

Here's an analogy: Think of the vaccine as a chocolate bar that melts easily. Just as there are ways to keep the chocolate from melting into goo, there are things the drugmakers did to protect their COVID-19 vaccines.


The first step, Liu says, was to modify the mRNA nucleosides — the "building blocks" of the RNA vaccine. "They've used modified versions because those are more stable," she says. This would be like changing the chocolate recipe so it's not quite so melty.

The next step was to use lipid nanoparticles, which, Liu explains, "is kind of like putting your chocolate inside a candy coating — you have an M&M, so the chocolate doesn't melt."

But even with the stabilized building blocks and lipid coating, the mRNA could still fall apart easily, which is why the vaccine is frozen.

"Everything happens more slowly as you lower the temperature," Liu says. "So your chemical reactions — the enzymes that break down RNA — are going to happen more slowly." It's the same idea as freezing food to keep it from spoiling.
Fascinating.

So what temperature is it at the time of injection? How do they raise the temperature to that point?
 
Idiots close to home
=========================

A gun show promoter, a firearms dealer, and a prospective gun show attendee have sued the state of Virginia, asking for an exemption to allow for a large 25,000-person indoor gun show to be held at the Dulles Expo Center.

Because the event is scheduled for this weekend, the case is moving quickly and a hearing has been scheduled for 10:00 a.m. Thursday morning.

Currently, in Virginia, social gatherings of more than 250 people are not allowed per Phase 3 guidelines..................




Brings a whole new meaning to the phrase "you can have my gun when you pry it from my cold, dead hand."
 

Here's some more good news.
At least it's not quite as deadly as it once was.

Good news is every person I know who has gotten it hasn't gone to the hospital... so hopefully the majority of cases stay that way and perhaps a slight immunity is happening?
 
Good news is every person I know who has gotten it hasn't gone to the hospital... so hopefully the majority of cases stay that way and perhaps a slight immunity is happening?

If I had to guess more people wearing masks also helps decrease the "viral load" for people that do come in contact with the infected making it less sever.
 
Fascinating.

So what temperature is it at the time of injection? How do they raise the temperature to that point?
Long term storage is that cold. Short term it can be in a freezer, then usually it’s warmed either on the counter for a few min or left to sit in the syringe for a brief amount to get warm enough for injection. It probably could be given cold (peanut butter antibiotic shot in the military) but that’s kinda uncomfortable.
 
If I had to guess more people wearing masks also helps decrease the "viral load" for people that do come in contact with the infected making it less sever.
That’s one of the guesses. Less viral load to begin with. Also coming off the summer when people’s vitamin D is higher, and more people are taking that supplement. The steroid they are using has had pretty remarkable results also, it’s what kept my in-laws out of the hospital.
 
Moderna CEO Stephane Bancel warns the Covid vaccine is “not a silver bullet" and public-health measures like wearing masks are still needed.

Well that's reassuring.
 
Moderna CEO Stephane Bancel warns the Covid vaccine is “not a silver bullet" and public-health measures like wearing masks are still needed.

Well that's reassuring.

That's a true statement for any vaccine. We still have outbreaks of measles in San Francisco and other anti-vax places despite an effective vaccine.

95% effectiveness is amazing but its not 100%, and if only 25% of the country takes it, then we will still have major problems with covid.
 
That's a true statement for any vaccine. We still have outbreaks of measles in San Francisco and other anti-vax places despite an effective vaccine.

95% effectiveness is amazing but its not 100%, and if only 25% of the country takes it, then we will still have major problems with covid.
Not for me. I'm becoming an anti-mask butt crevasse the week after my arm gets jabbed. Going to go straight to the grocery store and rub my balls all over the produce with no mask on and try to justify it with Jesus.
 
Not for me. I'm becoming an anti-mask butt crevasse the week after my arm gets jabbed. Going to go straight to the grocery store and rub my balls all over the produce with no mask on and try to justify it with Jesus.
At least wait until you get the second arm jab. And take pictures in the grocery store....strategically blurred out pictures.
 
Moderna CEO Stephane Bancel warns the Covid vaccine is “not a silver bullet" and public-health measures like wearing masks are still needed.

Well that's reassuring.
No, it won't be a silver bullet for all of the folks who won't get it. They'll still need to ignore mask wearing and just get their immunity the old-fashioned way.
 
Cases are climbing exponentially. If you didn’t already know someone who’s had COVID, you will soon. And as a virus becomes more common, it also becomes more likely to infect people who were following precautions.

That’s partly because our safety measures aren’t perfect, but it’s also because this spring and summer didn’t prepare us, emotionally, for the world we’re living in this fall. So here are a few reminders of how you can get the coronavirus even when you’re doing your best to avoid it.

Your bubble is bigger than you think
If you’ve established a bubble with a few family members and close friends, you may think you’re safe to hang out with them indoors and be physically close without a mask. But how can you know those people are actually COVID-free?

In most cases, you don’t. Your bubble isn’t just those people; in a sense, it’s those people plus everyone with whom they’ve interacted closely. (This diagram illustrates the concept perfectly.) Once you start including people from multiple other households, your network of potential COVID-carrying connections expands to dozens or, more likely, hundreds of people.

It’s tempting to think that if you know somebody well, they should be in your bubble. But if somebody has a job where they interact with the public, or if their kid goes to in-person school, or if they sometimes hang out with a friend who isn’t as cautious as they are, there’s a big ol’ hole in that bubble. The number of people who actually have a bubble as safe as they think it is, is vanishingly small...................




swiss cheese covid.jpg
 
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