Remember how we bloodied Carson Palmer last year in the preseason...they will have a little extra motivation, more than a normal preseason opener anyway. LIstening to them interviewed on Sirius the other day multiple players (especially O linemen) kept bringing that up.
I wouldn't be opposed at all to Drew just making a cameo and taking a very quick spot next to Payton on the sideline.
EDIT: Thanks for the visual to go along with my post! Ha!