Does this concern you?

In many ways it does. Also consider trying to maintain a lead and run the clock down with no run game. Also if you playing from behind you have to pass the ball ( especially if you have no run game) in which the other team can focus their defense on stopping the pass. I really don't see why this is such a "debate" it's basic football. You don't have to have played football to understand this.

And all of these factors can take place at Home and Away. There's nothing you've mentioned so far that is unique to the setting of the game, which is what the OP was discussing.