Ouch. Luckily I've made it through almost 90 online games without Brees getting hurt. Reggie on the other hand, gets hurt every other game because I use him so much. Last game for instance, he had 5 catches, and over 275 rushing yards, to go along with 4 punt returns.
BTW, depending on what the other person decided, D/Cs count as a loss 2/3 of the time.