No, you can use, for example, Lebron as many times as he plays in the week. You fill you starting lineup each day with whichever players you want. Some days you will only have a couple of people playing and others you will have every single one of your players playing. I usually start my best players the first part of the week and then depending on what statistics you need to beat your opponent in that category(points/rebounds/assists/etc) then you can decide if you want to play more centers or power forwards or point guards or shooting guards.