The Cato Institute thinks so (and most economists too)...
How Rising Tax Burdens Can Produce Recession
by William C. Dunkelberg and John Skorburg
William C. Dunkelberg is dean of the School of Business and Management at Temple University, and John Skorburg is chief economist for the Chicago Association of Commerce and Industry.
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This study presents solid statistical evidence demonstrating that taxes do harm the economy in a significant and consistent way. Since 1960 tax increases (measured by total tax receipts as a percentage of gross national product) have led to slowdowns in economic growth, and often to recessions. Likewise, when Washington has reduced federal tax burdens over the past 30 years, there has been a statistically significant positive economic and employment stimulus in the following year.
http://www.cato.org/pubs/pas/pa-148.html