4. There is very little evidence to suggest that ALS is caused by trauma. There is some evidence to suggest that they may be linked. However, the literature that everyone is pulling from is a 12 person study, TWELVE people. Most had a certain protein (TDP-43) that is associated with the disease. 3 developed the disease or a disease similar. This disease is so rare that it will be a long time before great headway is made, and trying to tease out cause/effect is near impossible be sample size is so limited. I feel for Steve Gleason (he is on my computer and phone wallpaper) but I would be extremely pressed to suggest that his disease is caused by his NFL career.