What position do we go for in the First Round?

This has the potential to be one of the most interesting drafts in history. Normally, you'd go BPA, but what if everyone grades out pretty much the same? That seems to be the case at a lot of positions this year. And, as important, there is some real depth in this year's draft. If that's the case, could you not make a case for drafting based on a run? If there is a run at one position, grab that position because there won't be anyone available in later rounds whereas there will still likely be a high grade player available at one of the other positions.