Lets say you were to win the powerball....

The jackpot for Saturdays drawing is 475 million, the cash payout is 302.4 million. I'd take the cash and after taxes (fed and state) I'd have about 155 million left.

First I'd set aside around 5 million to buy a house/toys/vacations/etc.

10 Million in laddered 5 year CD's to stay somewhat liquid.

60 Million in Stocks - S&P 500 represented companies would work for my purposes

40 Million in Treasury Bonds

40 Million in Muni Bonds