The reason I brought this up is because I was watching NFL Network and they were talking about who the best defenses in the league were. When they got to Carolina, they showed highlights of random plays throughout the season and every single one was of a different, bad offensive team.
If you look at who they've played, they've played against some of the most dysfunctional offenses in the league.
This will truly be a clash of an unstoppable force meeting an immovable object when we face them, but I don't think that immovable object has been truly tested. Seattle, on the road, across the country at noon is a completey different team. SF minus Vernon Davis isn't exactly a juggernaut either. I think we'll spread them out and throw for 350+ against them easily in the dome.