Remember e=mc2 is only a theory. A theory is something that isn't proven as a fact; it's just our best guess why things happen and how things will happen in the future. A basic assumptions in Einstein's theory is the speed of light is an absolute constant (is it absolutely true; who knows? is it possible there's more to the explanation that may be missing, etc.). Same with the theory of gravity...we know the apples fall from the tree and explain it with the theory of gravity. We're pretty confident about it as an explanation, but don't know for a fact that the current theories and related equations are all there is to it.
Additionally, in your example of travel you're limiting yourself to our current understanding of time and space. Time is another arena we know nothing about. We see time as a linear concept; who knows...there may be other ways to conceptualize the concept of time.