Saints at 49ers Oct. 28th
Take a look at a map of the city. Candlestick/Monster Park/name of the week stadium is pretty much in BFE. There are things to consider. You are probably flying. Renting a car night not be the best choice. Parking at a hotel in SF is expensive. Check out the public transportation. They may have buses and trains taking fans there. You might even be able to find a bar that has a shuttle or something.
If I remember the layout of the city, downtown is closer to the stadium than the wharf. I have not booked yet either. I will probably stay in downtown someplace. Don't know where yet.
This should be a fun trip too.
-Rene