If you have time to prepare your players for it you can some what contain it. Usually a option team like GT/Navy/AF if they have a solid match up week one or in a bowl game they don't fair so well. Talent difference in teams will show up quickly. Now it gets difficult during the grind of a season cause you have to throw out your whole base defense for a week. Auburn got to Champ running basically a flex/wish from shotgun it still works. Pairs very well with a team with a strong defense. LSU should have ran it in my opinion. Right personal very tough to stop.