Jack Crawford, a major character in the Thomas Harris novels Red Dragon and The Silence of the Lambs, was directly based on Douglas.[3] Crawford was played by Dennis Farina in the film Manhunter, by Scott Glenn in the film The Silence of the Lambs, by Harvey Keitel in the 2002 Red Dragon, and by Laurence Fishburne in the 2013 NBC series Hannibal.
According to Bryan Fuller, creator of Hannibal, the series' version of Will Graham is based in part on Douglas, namely in the character suffering a severe case of autoimmune encephalitis throughout the first season.