Actor/Actress with the Most Impeccable "Nerd" Credentials

gboudx said
If it's sci-fi genre as being "nerd", I'd submit Sigourney Weaver. Alien movies, Ghostbusters 1 and 2, Galaxy Quest, Avatar. Maybe there's more, those just come to mind.
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She also voiced the ship's computer in WALL·E and was the bad guy in Marvel's Defenders on Netflix, so that's a couple more.