Rule 17 is designed to allow the commissioner to correct major wrongs.
Here's the rule which I am sure you have all read: "The Commissioner has the sole authority to investigate and take appropriate disciplinary and/or corrective measures if any club action, non-participant interference, or calamity occurs in an NFL game which the Commissioner deems so extraordinarily unfair or outside the accepted tactics encountered in professional football that such action has a major effect on the result of the game."
Now, I think the key phrase is "outside the tactics encountered in professional football." Blown calls happen. Refs miss calls. So a blown call, no matter how bad in our eyes, won't rise to this level. If proof came a ref bet on the game, then maybe that. This is one of the rules used in deflategate and even then, they didn't replay games. So, can't see even with Rule 17, that a major outcome is changed.