| 1 | September 9 | Tampa Bay Buccaneers | L 40–48 | 0–1 | Mercedes-Benz Superdome | Recap |
|---|---|---|---|---|---|---|
| 2 | September 16 | Cleveland Browns | W 21–18 | 1–1 | Mercedes-Benz Superdome | Recap |
| 3 | September 23 | at Atlanta Falcons | W 43–37 (OT) | 2–1 | Mercedes-Benz Stadium | Recap |
| 4 | September 30 | at New York Giants | W 33–18 | 3–1 | MetLife Stadium | Recap |
| 5 | October 8 | Washington Redskins | W 43–19 | 4–1 | Mercedes-Benz Superdome | Recap |
| 6 | Bye |