I wouldn't put too much stock into our game against the Panthers - no action in the preseason, the heat, 10am PT start - I assumed we would lose. Goff was terrible, but he was also bad against the Raiders last year in week 1 after not playing in the preseason. I'm also assuming the Saints defense will be better than what it was Monday night.
The lack of pressure is concerning - if we don't get after Brees, I'm not sure we'll stop the Saints.
Offensively, as someone pointed out above, Goff is night and day home versus away - and in his four games against the Saints, he's been pretty good in each one. Those two factors combined, I think he will be fine. I assume the Saints will try to focus on stopping the run and we will be pass heavy.
Right now I think the Rams have a big advantage offensively with the two WRs that Lattimore is not covering.
Saints have a big advantage offensively against our DL (which is weird, because Aaron Donald) and with Kamara - I'm happy that, win or lose, we don't play another McCaffrey or Kamara again this season. Those guys are nightmares.