I'm a big stats believer, but stats can lie.
According to the stats, 25% of teams with a #3 seed will make the Super Bowl. This sounds bad, but remember that most years the playoffs are full of 9-7 teams that just slipped in.
This year the NFC is stronger than the AFC, and there are four teams -- Saints, Seahawks, Niners, and the Packers -- that could each easily be #1 seeds in a normal year. This is one of those outlier years where the strength of the 3-4 seeds is so good that I wouldn't rule out a run by one of them.
You have to look at the depth of the teams that will make it.
Give me the Saints this year and a number 3 and I like the odds much better than the average 3 in an average year.