Not talked about but

insidejob said

Agreed. Make the 53 be the actual 53 and if you've got injured players that can't go, they'll still count against the 53 instead of being inactive. I just hate seeing healthy scratches on the 53. It seems stupid and archaic.

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I would like to have the official NFL explanation to that rule. For players that are inactive, I feel bad for them because I know they want to play. Injuries will have happen in any game, and to be down a player or two and can't use some of the players on your own roster is ridiculous.