That Colts game is certainly the most dominant. We've been able to embarrass teams with miss-matches through the air.
One game that stood out to me the most and OP mentioned it was that Bills game a few years back. We have never, under Payton, run the ball more dominantly than we did that game. We straight up man-handled them and for a team thats always had the stigma of finesse and soft, it was such a great feeling to see us put the beat down on the Bills. What is even more impressive is that the Bills were 5-3 and 4-0 at home coming into that game. We didn't just beat a bottom dweller, we stomped a playoff team built on solid defense and run game, on the road.
That was the first game that came to mind when I read the question. It felt so dominant because we've almost never beat a team in that fashion. The 15 or so play drive that was all runs is something you see from the Bears, not the Saints. Beautiful.