What if Drew Brees has a change of heart and wants to return for 2021? Do we risk losing Jameis like we did with Teddy or do we honor Drew's wish

Didn't Drew have to think about whether he wanted to come back this year? I can't see him trying to play another year beyond this season. I think it would be unwise.
Usually "running it back" which is a hardcourt term for one more game bites you in the arse. This is the second time Drew has ran it back after the NFC Championship game against the Rams. A third would most certainly be disastrous.

Edit: I think this year Drew leaves it all on the field. I have a feeling he is going to use every ounce of football juice and will power he has left to try to get us to the big game.