I'm expecting to see this in the first quarter:
1st Down - Incomplete passes with miscommunication between Brees and the intended target. Maybe a few holding calls thrown in for good measure.
2nd Down - 2nd and 10 = random running play with the back hit at or behind the line of scrimmage. Holding if it's a big run.
3rd Down - 3rd and 15 = 7 yard completion or 16 yard completion brought back due to holding.