It's affecting our ability to check out new comics. Not just because we don't want to spend the money on something that we might not like, but because the comic shop owner won't order very much because they don't want to be stuck with expensive inventory.
Two weeks ago I asked my local lcs owner about "Nocterra" from Image Comics. He said that he only buys a couple of each title unless he gets a lot of interest. He started talking about 2nd and 3rd printings. I told him that I'm not interested in that because you're paying the same price for something that is almost guaranteed to be worthless going forward but I might be interested in subscribing through the shop if I get interested in the run.
All of the local shops are getting really tight. Captain America, for instance. If you don't subscribe, you probably won't find an issue. I have 3 local shops and you won't find a copy of a new issue. The good thing is that, if an issue, or a run gets popular it'll be worth something because very few people have it.