But that's an interesting thought! From the point of view of that reality, I don't think it would be that, because the Loki and Sylvie on Lamentis aren't that reality's Loki, he's already dead, so their dying there should be irrelevant. But if the TVA's 'sacred timeline' encompasses multiple timelines (which it appears to, to at least some extent, with (e.g.) Steve Rogers living an alternate life out), then perhaps?
It could also just be that the sacred timeline, nexus event, things are much more arbitrary than we've been led to believe.
Or it could be that I'm overthinking this. Definitely that one.