Drew Brees tweets 3 rule changes he wants the NFL to make

Bring the game back to it's early days.
The game is too regulated.
The refs have too much influence in the outcome of games due to the overabundance of rules that allow for subjectivity on their part.
I care for the players as much as the next guy.
I hate seeing injuries. But injuries are going to happen.
When rules are implemented to penalize hits to the knees and head, the integrity of the game is compromised.
We are witnessing that now.
How many times have we seen a "roughing the passer" penalty called when a hand brushes the QB's head, or when a tackler lands at his feet or thigh?
Or when the defender is blocked into the QB's knee, or close to it, yet the ref calls the penalty?
The same situation exists for hitting the receiver "from the knee down".
Again - no one wants a receiver, or any player, to get hurt.
But to limit where a player can hit the opposing player to tackle him [ except for obvious targeting to the head or knee ] makes the traditional game of football obsolete, and puts too much influence into the hands of the officials.

And Stalwart385's statement on PI penalties is valid.
I don't like review of plays for PI because of how much it slows the game down, but this situation comes down to the integrity of the refs. And their training.
The NFL doesn't want to stop the spot foul rule for PI because defenders will interfere with the receivers more often, especially on deep pass plays, thus avoiding a big gain.
I'm not sure how justified this reasoning is.
I have some reservations.
To your last point. A possible solution would be to make repeated PI by the same player an ejectable offense. I.E. You have a DB that keeps dragging a WR down when he is beat, he gets away with a 15 yard penalty once, but he does it again, flagrantly, he's out. Obviously there is nuance here, and it may not be that cut and dry, but individual consequences would straighten some of this up. You could also impose fines on PI calls. Lots of ways to incentivize clean play without basically giving free completions. A penalty that results in a 55 yard gain is absolute BS.