I'll 2nd Titties and Beer. A very close 2nd favorite is Dumb All Over. listen to the lyrics, consider that it was released in 1981, and then recognize just how far ahead of his time Zappa truly was.
Yup, I saw Zappa in 1981 at the Saenger, it was the Dumb all Over tour....his band was like the most bizarre orchestra you could ever imagine....he just sat on his stool and played incredible guitar....incredible show....