Barack Hussein Obama The Closet Muslim

Yea but will the powerful Jewish lobby and its interests cause trouble for him if he is the nominee or VP nominee?

Possibly. But I doubt it.
My impression is that most Jews in the USA are not vehemently anti-Palestine. I mean they want candidates to express support for Israel, but that doesn;t mean they are going to turn on you for expressing support for Palestine as well.
Of course, there is a more right-wing element that feels otherwise. But there are few of them in this country - and they would never support Obama anyway.