The bottom line is that we have no clue what we can expect from future viruses. Frankly all of the vaccines are limited in the length of time they will produce antibodies. Also it's not impossible that we could encounter a virus that is resistant to everything we are using now to avoid getting a severe reaction to an infection. Hopefully the mutations will continue to be the type that will not threaten the lives of people in general. But if we are faced with a resistant strain that is also deadly to otherwise healthy people, it's unlikely that the population will endure going through another round of extended isolation & closures as we saw in 2020-21. We simply can't deal with another deadly version without seeing a serious toll on the population.