Could you go on the run?

Yes but you don't necessarily have to go off the grid to go on the run. You'll just need a new identity.
Agree. The key is not giving up tech and comfort. The key is money. If you have a certain amount of money (and assuming the hypothetical allows time and access to get it in cash) then the world is your oyster. Cross to Mexico, buy a fake passport, then go to any other country where you speak the language, buy a small house, and live.