Cosby Show - Claire & Denise Huxtable (and not on the show because she was a kid but Rudy grew up to be smokin hot)
Facts of Life - the show presented Blair as the beautiful one but looking back it was clearly Jo, and Tootie
Living Single - all the main cast but especially Kim Fields again
Threes Company - I always liked Janet more than Chrissy
Cheers - Rebecca & Lilith
Frasier- Roz & Daphne
not a sitcom but Black Lady Sketch Show - Robin Thede, Gabrielle Dennis (my favorite), Skye Townsend (Robert Townsend’s daughter)
Hot in Cleveland - Jane leaves again, Valerie Bertinelli and Wendie Malick
Mary tyler Moore Show - Mary and Valerie Harper