Highest Draft Pick to Not Make 53

https://en.wikipedia.org/wiki/Jim_Detwiler
Detwiler signed with the Colts in May 1967. He received a $50,000 signing bonus and played in a couple preseason games in 1967, but his knee was still hurting. He had more surgery on the knee and missed the entire 1967 season. He failed to make the team in 1968, and his professional football career was over. He is the most recent 1st round NFL Draft choice to have never played a game in the NFL.