However, a presidential candidate's spouse going more the a quarter of a century without feeling pride for her country......They'll have a lot of fun with that one.
The real problem, of course, is it feeds one of the classic Republican charges against the Democrats, the whole "you hate America"/"you apologize for America"/"I love America more"/etc deal.
Said during the general election it would be one of those oft-repeated Limbaugh/Hannity lines that ends up generating voter turnout for the Republican base. As it is, this'll probably fade within a day (unless Obama stupidly decides to address it and it carries into another news cycle, then it's not a "soundbyte" it's a "story").