Loki Disney Plus - Trailer

"We are certainly thinking about how we can continue to tell TVA and Loki base stories," series co-executive producer Kevin Wright told ComicBook. "What I would say is, season one and season two were always conceived as two chapters of the same book. We want to close this book." Wright added: "I think there's a lot more books on the shelf, though."

I agree with Dave, sure feels like it's the end of this series...but still more to come with the character. Likely just movies, though.
I'd add cameo appearances in other shows as well. At least I hope that's the case.