No doubt you have to fit the offense to your personnel. I'm just looking to identify guys we have that can credibly line up in multiple positions because it appears that in addition to all the motion and outside zone, a corner stone of the new system is likely to be using formations with versatile players to dictate how the defense will play you so that you can try to get the defense in a base while you are passing and in nickel/dime while you are running. It won't necessarily be looking for a "Deebo" or a "Kittle" but a guy like Hill who can credibly line up out wide and then motion into the backfield or the reserve, would help with that disguise. As would a guy like Bowden.
But, yeah, the system varies based on the players. For instance, Miami runs this system well without great blockers at WR and without the versatile TE.