The MCU Fantastic Four

Not doing the big bad is a bold move

it can be done (Batman Begins not using Joker) but it’s a risk

i wasnt a huge FF fan but wasn’t Doom with them on the shuttle?

it would be doubly odd not to use him if that’s the case

Supposedly Marvel is very aware that Doom has been badly screwed up two previous times and has bigger plans for him than just a FF foil.

In the original origin, no. Maybe in the Ultimate Universe he was also on the shuttle. His origin is closely tied with Reed Richards but there's talk this won't be an origin story.