The unit coalesced in the early 1960s as the de facto house band for Phil Spector and helped realize his Wall of Sound production style. They subsequently became the most requested session musicians in Los Angeles, playing behind many popular recording artists including Jan and Dean, Sonny & Cher, the Mamas and the Papas, the 5th Dimension, Frank Sinatra, and Nancy Sinatra. The musicians were sometimes used as "ghost players" on recordings credited to rock groups, such as the Byrds' debut rendition of Bob Dylan's "Mr. Tambourine Man" (1965), the first two albums by the Monkees, and the Beach Boys' 1966 album Pet Sounds.
The Wrecking Crew's contributions to so many hit recordings went largely unnoticed until the publication of Blaine's memoir and the attention that followed. Keyboardist Leon Russell and guitarist Glen Campbell were members who became popular solo acts, while Blaine is reputed to have played on more than 140 top-ten hits, including approximately 40 number-one hits. Other musicians who formed the unit's ranks were drummer Earl Palmer, saxophonist Steve Douglas, guitarist Tommy Tedesco, and keyboardist Larry Knechtel, who became a member of Bread. Blaine and Palmer were among the inaugural "sidemen" inductees to the Rock and Roll Hall of Fame in 2000, and The Wrecking Crew was entirely inducted into the Musicians Hall of Fame and Museum in 2007. In 2008, they were the subject of the documentary The Wrecking Crew.