After the Deadpool movie, I've heard speculation that their Earth will now be on a course for incursion with 616, thus we'll get X-Men vs Avengers. After Secret Wars obviously.
If I had to guess, I'd say that Secret Wars ends with the timelines merging into a new singular Marvel Cinematic Universe. Then we start with the mutant stuff and how society reacts to that (spoiler: not great), establish the new (or returning) X-Men, etc. Then the big finale to that phase is Avengers vs X-Men.