Misdirection relies on OL timing and execution. That's hard to do after substituting two OL during the game. Look at the play were both guards pulled opposite directions and ran into each other.
Kubiak adjusted to what the players he had could do and that kept the Saints in the game. In games like today, Payton pressed too hard to stick to his plan which caused points off of turnovers. I think if Payton was calling the offense today, the game would have been a blowout in favor of the Eagles by halftime.