QB Derek Carr will miss multiple games with oblique injury, at least 2 weeks; Derek Carr is week-to-week per Dennis Allen

WilliamBrees said
Even if we do go 2-5. The only games I'm worried about after are Atlanta and Washington. However, our defense is not gonna struggle against Denver. They are not a good offensive team at all.

I’m gonna wager a guess that Payton has some experience calling plays against Dennis Allen’s defense.