That doesn't really explain the issues with no being able to run the ball against a giants DL with UDFAs starting while you have your entire starting OL and #1 RB healthy. Yes, you don't have the QB power plays with Hill hurt, but you still should be able to run the ball and it looked like it was mostly the play calling and refusal to use Miller that was stopping them.
And having to adjust week to week and in game due to injury and/or opponent is kind of a major part of what NFL OCs do.