Everyone saying yes, we should draft him would be screaming next year about our lack of quality depth on the OL/DL (again).
RB is the easiest position in football to find a suitable starting-caliber player. Drafting Jeanty that high would set us back even further.
Aside from all of that, Jeanty already has a lot of mileage on him (as already pointed out), and he also doesn't seem to do much for you in the passing game.
Pass.