It’s a lot more likely he would be an OLB in a 2-4-5 front. The 3-4 is going to be the exception, DC’s want seven guys back in a passing league (versus five guys in the LOS).
Maybe. No doubt we won't see much base 3-4 given that it's a passing league, Nickel is practically a team's base. I know Staley ran some 2-4-5 Nickle but he also used some 3-3-5 Nickel.
Anyway, I'm just not sure Cam has the speed or agility to play in space at this point in his career and I think he would be better used as a run stopper now rather than as an edge rusher. So I see him more as a downlineman in the 2-4-5 or a DE in the 3-3-5 Nickel. Although in the long run Cam isn't going to be the cornerstone of the defense anymore and likely won't be here longer than another year.