https://pmc.ncbi.nlm.nih.gov/articles/PMC5405788/
"Conclusion:
There is no correlation between the number of carries by college running backs and future injury risk or performance during their early NFL career."
That's interesting but I wonder if there is any work done on if it affects the longevity of a RBs NFL career? That's really more my concern than whether a RB would get injured early in their career. That study only looks at the first 3 years of a RBs career.