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Yeah. There's some speculation that J. August Richards (the hooded guy who rescues someone from the building. Also, Gunn on "Angel.") is playing a character from the comics. Some have speculated Luke Cage, but I REALLY doubt they'd use that character for a TV show. He's not a household name, but I still see him more as a movie character than a TV one. Evidence seems to point to him being D-List Avengers/New Warriors character Rage, but that's just based on a panel of that character appearing in the Marvel logo before the preview. He could be an original character for all anyone knows.
Even if he is, I really think this show could be a good chance for the producers to bust out their old Official Handbook of the Marvel Universe and showcase some characters that will never in a million years be fit for movie screens. For ever A or B list character Marvel has there are four or five C or D listers. They can do a whole arc focused on Squirrel Girl!
You're looking for a MoonKnight cameo aren't you?