COVID-19 Outbreak (Update: More than 2.9M cases and 132,313 deaths in US) (11 Viewers)

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I feel the need to explain that my "Face palm" emojis is NOT for you, the posters, but the content that THIS is happening. Like, are humans this stupid and corrupt. Thousands and thousands of lives are at stake, This really isn't the time for political gamesmanship. I am just so frustrated reading this. It's truly disheartening.

I appreciate the clarification, but not necessary. I totally got it - but thanks :)
 
Yeah, 45 people is an awfully small sample size, but, about as well as you can expect for this stage. Good news, hopefully.

Those Phase 1 results were about the best possible results you would ever expect to see on this type of vaccine.

The 45 people number is very low, but it is about the right number of people for a Phase 1 trial. (I got this info from somebody who knows about this sort of thing.) Phase 2 is, in many ways, very similar to Phase 1, just with way more people. Phase 2 is basically to confirm what the Phase 1 results were. It looks like they (FDA/NIH, whatever other governmental body has anything to do with it) are fast tracking this and Phase 2 should be done much sooner than normal. From reading the reports on the Phase 1 trial, it looks like it will take a couple of months to get results from Phase 2, after they start that process. If Phase 2 goes well, then they move to Phase 3, which is a larger number of people than Phase 2, and it looks at Safety and Efficacy. Does the vaccine (drug candidate) look to be "safe" meaning no major side-effects, etc., AND is the vaccine Effective, does it prevent exhibit a response that prevents infection. (I think it is possible...this is just a hunch....that Phase 3 might be a different type of study with this virus. They might do a much broader release of it and see what happens. This is just a hunch. Honestly I would give the vaccine candidate to all of the politicians in Washington, DC....every last one of them, and if it works...great, if they all keel over....great.)

I believe Moderna has said that they do not intend to make a profit from this. They have gotten a lot of funding from the Government to work on this, as have many other traditional Pharmaceutical companies and newer biopharma companies. It is possible/likely that the "deal" that was made with the government was, we will throw money at this, you will work your tails off, and if it works you will essentially make the vaccine and distribute it "at cost" to the public. It would be a huge "win" for Moderna, a massive scientific coup and a massive public relations win. It is also possible that the government has told these companies that if their vaccine winds up working, they get a nice bonus payment. Like completing a bridge ahead of schedule. Moderna is a cutting edge company and if they can get this to work, it would prove up a lot of the way they do science.

There's a massive effort behind the scenes of government funding on this. It is not a small effort.
 
The President and "a lot" of people take hydroxychloroquine to prevent Covid-19 infection.


I'm 99.9% sure he's lying. First of all, he lies about almost everything. Second of all, he thinks this is some hill for him to hold for some absurd pseudo-political reason, and third of all, he's reportedly very particular about getting sick and is even more obsessive about it than many people.

Just seems to me that this is the kind of thing he says he's doing, but he isn't actually doing. And that actually makes it worse.
 
I'm 99.9% sure he's lying. First of all, he lies about almost everything. Second of all, he thinks this is some hill for him to hold for some absurd pseudo-political reason, and third of all, he's reportedly very particular about getting sick and is even more obsessive about it than many people.

Just seems to me that this is the kind of thing he says he's doing, but he isn't actually doing. And that actually makes it worse.

I believe I read somewhere that there is a shortage of this drug already, and comments like this won't help.
 
I'm 99.9% sure he's lying. First of all, he lies about almost everything. Second of all, he thinks this is some hill for him to hold for some absurd pseudo-political reason, and third of all, he's reportedly very particular about getting sick and is even more obsessive about it than many people.

Just seems to me that this is the kind of thing he says he's doing, but he isn't actually doing. And that actually makes it worse.
......... I just can't..
 
The President and "a lot" of people take hydroxychloroquine to prevent Covid-19 infection.

It has now been proven that it can cure 92% of covid-19 cases in people that have never been infected.
 
The University of Notre Dame is resuming on-campus classes two weeks earlier than normal, canceling Fall Break in October, and ending the semester before Thanksgiving and things get really cold in South Bend. An interesting approach:

 


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So when will we see "falling from high places" on the list of potential Covid19 symptoms
 
I believe Moderna has said that they do not intend to make a profit from this. They have gotten a lot of funding from the Government to work on this, as have many other traditional Pharmaceutical companies and newer biopharma companies.

This needs to never be forgotten as we work toward a vaccine.

The model of America up to this point with pharmaceutical drugs(and a lot of government funding) is textbook Lemon socialism. America puts our tax money on the hook for much of the foundational and early research and development, all the testing and trials. Then the private market carries the drug across the finish line and all the profits are realized entirely by the private sector.

The private sector leverages their exclusivity to mark up the price, consumers pay even more out of pocket, then once the end of their patent approaches they use all sorts of corrupted laws to extend their exclusivity rights so they can keep gouging consumers.

And not to be even more of a Debbie Downer, but, its worth keeping in mind:

Established in 2010, Moderna has never brought a product to market, or gotten any of its nine or so vaccine candidates approved for use by the FDA. It has also never brought a product to the third and final phase of a clinical trial.


Everyone has to start somewhere, and venture capital is pretty much built on the idea of investing in ten ideas and hopefully hitting on one, and their work with MERS and the NIH gives me some hope, but I am not going to let myself be more than incredibly cautiously optimistic until we get through stage 2 and see some promise in phase 3.
 
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