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Although I'll buy Guido's take that it was to punish Tyrion I can live with that more than I can "well she saw The Red Keep and kinda forgot about innocent children's lives" bullshirt answers that D&D keep pumping out in these behind the scenes after the episodes. I think this season would be ten times better with out having to listen to those guys try and explain why they did what they did. At least the fans can come up with better logic reverse engineering everything to make up for their shirtty writing.
Yep, I don't buy their explanation. It just seemed obvious to me that she had finally snapped. The Targaryen mad queen gene had activated because of all the things that had happened to her and she just lost it and went full on mad queen. I think the final straws were Messandei's death (which was significant since she was sitting on her dragon, on the wall right next to where she was killed) and the fact that after Drago, she had finally found a man she could love, Jon, but because she is her aunt, he can not love her back. That finally made her snap. That, to me, is a much more reasonable explanation.