SaintMeaux
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Not really skits, but Sandlers holiday songs are still played every year around Thanksgiving and Hanukkah.
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As were a couple others that haven't been mentioned: Billy Crystal (Fernando)'s "You look mah-velous!" Everyone was waking around saying that- my excuse is that I was only 6 when it came out. ... And the other is Jon Lovitz: "That's the ticket!" That phrase was so ubiquitous that you had no chance of escaping it; people pretty much used it in any context you could imagine for about two years in the mid-80s...
I would second Weekend Update. It has sparked an entire genre of television.
I'd also give points to Dana Carvey's George Bush impersonation. I think that went a long way to defining how people viewed Bush. To this day I hear people quote Carvey and claim they are quoting Bush when really it was Carvey that said it. George Bush really isn't remembered as himself, he's remembered as Carvey's lampoon of him.