Personally, I'd never make a win-loss bet on the Saints one way or the other. There's emotion involved and if you're trying to make money, emotion should be removed from the equation. If the Panthers are your team, I'd stay away from all win-loss bets involving them.
Saints will cover. Many will think week 1 performances can be overweighted and go contrary. Not here. And this is a betting opinion; I have no trouble taking the points if the Saints are giving too many.